Nintendo has pledged to "bring E3 to you" via a partnership with US retail chain Best Buy.
The deal means that select unreleased Wii U games will be playable across 100 stores in America during E3 week.
Specific locations have yet to be announced, but this is believed to be the first deal of its kind and will spread the reach of Nintendo's show floor across the US.
The US partnership was announced by Nintendo of America president, Reggie Fils-Aime. During a Nintendo Direct announcement on Friday, he said "we are bringing E3 to the people, giving them an exclusive glimpse into the future of Wii U".
It is unknown which games will be playable, though Nintendo previously announced that both a new 3D Mario game, as well as a Mario Kart and Smash Bros title will be playable at E3.
The E3 2013 show runs from June 11 to 13 at the Los Angeles convention centre.
Facing a global commercial underperformance of the Wii U, in April Iwata admitted that the company has "not been able to solidly communicate the product value of Wii U to our consumers yet, which has been a grand challenge for us".
Nintendo believes that this partnership with Best Buy will give more consumers hands-on experience and help remedy that challenge.
Both Fils-Aime and Shigeru Miyamoto will host an E3 showcase during the week.